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Copy Proxifier.app to Applications folder and launch Proxifier.
By default, Proxifier is configured to bypass all network connections. You can still see connections and DNS requests if you enable verbose output Log->Output Level->Verbose.
Proxifier can process the connection directly (without a proxy server). To enable this mode, set Handle Direct Connections option under Profile->Advanced. It can be useful to troubleshoot problems and utilize some features of Proxifier like traffic dumps, bandwidth and connection monitor, etc.
To make the connections work through a proxy server or a chain of proxy servers, you must first define a proxy server in Proxifier. Click Proxy Servers... in the Profile menu or click on the icon located on the toolbar:
If you were using proxies before you installed Proxifier you should disable any built-in proxy settings. Your applications should then be configured to connect “directly” to the Internet (rather than through proxies).
Click the Add button in the new dialog window:
Fill in the form specifying the details of the proxy server (address, port, protocol, etc.) that you want to add and click OK:
Proxifier will ask you whether or not you want to use this proxy by default. Click Yes to set it as the target for the Default Proxification Rule. You can change this anytime later at Proxification Rules.
Your proxy server will appear in the list:
From now on all new connections (TCP/IP) will be established through the specified proxy server while Proxifier is running.
If you only want to tunnel specific connection, not all of them, use Proxification Rules.